Table 1.
Number of adverse drug reactions (ADRs) distributed for the suspected drug (quinolone) and for the System Organ Class (SOC) among those reported in the Italian spontaneous reporting system.
| System Organ Class | |||||
|---|---|---|---|---|---|
| Nervous system disorders | Musculoskeletal and connective tissue disorders | Psychiatric disorders | Other SOCs |
Total SOCs | |
| 1° Generation | 50 | 19 | 23 | 353 | 445 |
| • Cinoxacin | 13 | 1 | 1 | 111 | 126 |
| • Pipemidic acid | 2 | 0 | 0 | 75 | 77 |
| • Norfloxacin | 35 | 18 | 22 | 167 | 242 |
| 2° Generation | 534 | 514 | 290 | 6,950 | 8,288 |
| • Ciprofloxacin | 495 | 491 | 265 | 6,687 | 7,938 |
| • Lomefloxacin | 21 | 13 | 9 | 218 | 261 |
| • Ofloxacin | 9 | 7 | 2 | 125 | 143 |
| • Rufloxacin | 9 | 3 | 14 | 20 | 46 |
| 3° Generation | 999 | 1,094 | 788 | 9,877 | 12,758 |
| • Levofloxacin | 796 | 1,025 | 682 | 8,463 | 10,966 |
| • Moxifloxacin | 197 | 52 | 100 | 1,355 | 1,704 |
| • Pefloxacin | 6 | 17 | 6 | 59 | 88 |
| 4° Generation | 36 | 54 | 17 | 343 | 450 |
| • Prulifloxacin | 36 | 54 | 17 | 343 | 450 |
| Total | 1,619 | 1,681 | 1,118 | 17,523 | 21,941 |