TABLE 3.
Single-cell cluster enrichment of GO: biological process.
| GO category | P-value |
| Cluster 0 (Epithelial cells) | |
| Negative regulation of cell motility | 2.0631e−7 |
| Negative regulation of cell migration | 9.0561e−7 |
| Extracellular matrix organization | 8.8733e−8 |
| Negative regulation of cellular component movement | 3.3807e−7 |
| Negative regulation of locomotion | 6.5930e−7 |
| Cluster 1 (Epithelial cells) | |
| Extracellular matrix assembly | 0.0000088218 |
| Collagen metabolic process | 0.0000034043 |
| Extracellular matrix organization | 4.0817e−9 |
| Extracellular structure organization | 2.7391e−8 |
| Cell growth | 0.0000029102 |
| Cluster 6 (Epithelial cells) | |
| Protein trimerization | 0.00018877 |
| Cellular response to amino acid stimulus | 0.000026320 |
| Cellular response to acid chemical | 0.000072229 |
| Lung development | 0.00018877 |
| Respiratory tube development | 0.00022526 |
| Cluster 2 (Basal epithelial cells) | |
| Collagen biosynthetic process | 0.000040927 |
| Collagen metabolic process | 0.00018409 |
| Protein localization to plasma membrane | 0.000059560 |
| Bone mineralization | 0.000055506 |
| Transforming growth factor beta receptor signaling pathway | 0.000045449 |
| Cluster 11 (Ciliated epithelial cells) | |
| Axoneme assembly | 0 |
| Cilium movement | 0 |
| Cilium or flagellum-dependent cell motility | 1.9154e−10 |
| Cilium-dependent cell motility | 1.9154e−10 |
| Axonemal dynein complex assembly | 1.9154e−10 |
| Cluster 3 (Stromal cells) | |
| Collagen fibril organization | 0.0000091862 |
| Collagen metabolic process | 0.0000037847 |
| Protein processing | 0.000068852 |
| Extracellular matrix organization | 4.5168e−9 |
| Extracellular structure organization | 7.6653e−8 |
| Cluster 4 (Stromal cells) | |
| Collagen fibril organization | 0.0000043023 |
| Embryonic skeletal system development | 0.000014268 |
| Negative regulation of cellular response to growth factor stimulus | 0.0000039117 |
| Collagen metabolic process | 0.0000068214 |
| Extracellular matrix organization | 3.7315e−11 |
| Cluster 5 (Stromal cells) | |
| Collagen fibril organization | 1.5268e−9 |
| Regulation of bone mineralization | 5.1255e−8 |
| Regulation of biomineral tissue development 6.3049e−9 | |
| Bone mineralization | 7.6798e−10 |
| Biomineral tissue development | 1.7298e−11 |
| Cluster 7 (Vascular endothelial cells) | |
| Negative regulation of cellular component movement | 2.5616e−8 |
| Regulation of plasma membrane bounded cell projection | 4.2233e−8 |
| Regulation of cell projection organization | 5.2664e−8 |
| Angiogenesis | 6.4595e−11 |
| Blood vessel morphogenesis | 9.2663e−11 |
| Cluster 12 (Lymphatic endothelial cells) | |
| Endothelial cell differentiation | 0.0000057055 |
| Endothelium development | 0.0000080317 |
| Sprouting angiogenesis | 0.000010961 |
| Negative regulation of angiogenesis | 0.0000091829 |
| Negative regulation of blood vessel morphogenesis | 0.000013967 |
| Cluster 13 (Pericytes) | |
| Membrane repolarization | 0.000084352 |
| Actin-mediated cell contraction | 0.0000096969 |
| Actin filament-based movement | 0.000018559 |
| Notch signaling pathway | 0.0000090719 |
| Regulation of heart contraction | 0.00017208 |
| Cluster 8 (Macrophages) | |
| Tumor necrosis factor production | 5.0342e−8 |
| Regulation of tumor necrosis factor production | 3.3417e−8 |
| Cellular response to molecule of bacterial origin | 4.9622e−8 |
| Response to molecule of bacterial origin | 2.1447e−8 |
| Response to organonitrogen compound | 3.3417e−8 |
| Cluster 9 (Monocytes, Dendritic cells) | |
| Cellular response to radiation | 0.000033926 |
| Activation of innate immune response | 0.000071442 |
| Tumor necrosis factor production | 0.000017344 |
| Regulation of tumor necrosis factor superfamily cytokine production | 0.000043714 |
| Tumor necrosis factor superfamily cytokine production | 0.000043714 |
| Cluster 10 (T-cells, NK cells) | |
| T-cell receptor signaling pathway | 5.3595e−7 |
| Positive regulation of leukocyte cell-adhesion | 3.9513e−7 |
| Positive regulation of lymphocyte activation | 2.3319e−7 |
| T-cell differentiation | 9.7306e−8 |
| T-cell activation | 4.4670e−12 |
| Cluster 14 (ILC2s) | |
| Positive regulation of leukocyte differentiation | 0.0000018086 |
| Regulation of lymphocyte differentiation | 0.0000011529 |
| Positive regulation of hemopoiesis | 0.0000013987 |
| Positive regulation of lymphocyte activation | 0.000002159 |
| Regulation of hemopoiesis | 1.1023e−7 |
| Cluster 15 (B-cells) | |
| B cell receptor signaling pathway | 2.9347e−11 |
| Regulation of B cell proliferation | 7.1741e−8 |
| B cell proliferation | 3.0189e−8 |
| B cell activation | 6.8834e−15 |
| Antigen receptor-mediated signaling pathway | 2.8936e−9 |
| Cluster 16 (Melanocytes) | |
| Sister chromatid segregation | 8.2230e−10 |
| DNA packaging | 2.8980e−9 |
| DNA conformation change | 5.2742e−10 |
| Chromosome segregation | 9.2013e−11 |
| Nuclear chromosome segregation | 1.4193e−9 |
The five GO categories with the highest enrichment ratios are listed for each single-cell cluster.