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. 2020 Apr 15;11:671. doi: 10.3389/fimmu.2020.00671

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Copyright © 2020 Zhang, Li, Vanarsa, Gidley, Mok, Petri, Saxena and Mohan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximal expression of CD163 within infiltrating M2 macrophages in kidneys of 24 patients with lupus nephritis. (A) Clusters of kidney cells identified with public scRNA-seq data. Cluster annotations: CM0, CD16 + macrophages, inflammatory; CM1, CD16 + macrophages, phagocytic; CM2, tissue-resident macrophages; CM3, cDCS; CM4, CD16 + macrophages, M2-like; CT0a, effector memory CD4 + T cells; CT0b, central memory CD4 + T cells; CT1, CD56^dim CD16 + NK cells; CT2, CTLs; CT3a, Tregs; CT3b, TFH-like cells; CT4, GZMK + CD8 + T cells; CT5a, resident memory CD8 + T cells; CT5b, CD56^bright CD16- NK cells; CT6, ISG^high CD4 + T cells; CB0, activated B cells; CB1, plasma cells/plasmablasts; CB2a, naïve B cells; CB2b, pDCs; CB3, ISG^high B cells; CD0, dividing cells; CE0, epithelial cells. (B,C) CD163 expression on kidney cells, predominantly on macrophages.