Table 1.
Anti-proliferative activities of all the synthesized compounds against four tumor cell lines and a normal cell line.
| Compds. | R1 | R2 | IC50(μM)a | ||||
|---|---|---|---|---|---|---|---|
| A549 | HepG2 | Hela | MCF-7 | WI-38 | |||
| a1 | 4-F | –CH3 | 42.80 ± 2.41 | 93.57 ± 4.59 | 35.99 ± 6.42 | 60.71 ± 4.56 | 141.98 ± 4.52 |
| a2 | 4-Cl | –CH3 | 45.8 ± 1.68 | 88.7 ± 2.34 | 35.3 ± 3.22 | 58.9 ± 1.02 | 119.64 ± 3.43 |
| a3 | 2-Cl | –CH3 | 43.8 ± 7.82 | 73.6 ± 4.34 | 30.4 ± 2.38 | 64.3 ± 4.21 | 162.14 ± 1.89 |
| a4 | 4-Br | –CH3 | 51.04 ± 2.23 | 65.54 ± 3.69 | 31.39 ± 0.94 | 56.71 ± 10.01 | 198.89 ± 4.23 |
| a5 | 4-I | –CH3 | 45.6 ± 2.81 | 68.9 ± 1.95 | 35.8 ± 2.43 | 63.2 ± 4.32 | 157.66 ± 3.16 |
| a6 | 4-CH3 | –CH3 | 39.2 ± 3.88 | 74.9 ± 2.05 | 19.6 ± 3.92 | 44.8 ± 2.01 | 97.24 ± 6.36 |
| a7 | 4-NO2 | –CH3 | 43.8 ± 4.82 | 88.3 ± 8.64 | 25.8 ± 8.93 | 58.7 ± 3.86 | 210.81 ± 4.32 |
| a8 | 4-N(CH3)2 | –CH3 | 38.6 ± 0.92 | 65.4 ± 4.32 | 29.6 ± 3.22 | 34.5 ± 1.68 | 200.05 ± 2.83 |
| a9 | 4-CF3 | –CH3 | 25.86 ± 1.46 | 33.36 ± 0.95 | 11.15 ± 3.24 | 49.87 ± 7.77 | 95.16 ± 3.16 |
| a10 | 4-C6H5 | –CH3 | 19.8 ± 2.11 | 26.8 ± 3.22 | 38.4 ± 1.01 | 48.4 ± 2.21 | 125.9 ± 7.83 |
| a11 | naphthalene | –CH3 | 26.6 ± 2.81 | 29.2 ± 3.22 | 21.8 ± 2.42 | 38.4 ± 2.12 | 108.7 ± 4.63 |
| a12 | [d] [1,3] dioxole | –CH3 | 28.4 ± 2.01 | 37.6 ± 2.89 | 35.6 ± 0.89 | 44.6 ± 4.62 | 146.96 ± 3.82 |
| b1 | H | –H | 33.11 ± 0.96 | 84.50 ± 1.33 | 90.37 ± 2.21 | 94.30 ± 15.32 | 194.30 ± 5.32 |
| b2 | 4-F | –H | 49.53 ± 0.98 | 65.51 ± 0.84 | 60.44 ± 1.76 | 61.47 ± 8.64 | 140.07 ± 7.05 |
| b3 | 4-Cl | –H | 49.26 ± 6.39 | 82.72 ± 3.09 | 95.17 ± 1.79 | 52.70 ± 13.94 | 152.70 ± 3.94 |
| b4 | 4-Br | –H | 44.02 ± 2.93 | 66.71 ± 3.34 | 55.89 ± 4.06 | 65.05 ± 15.02 | 191.69 ± 5.16 |
| b5 | 4-I | –H | 48.33 ± 0.92 | 90.31 ± 8.18 | 60.98 ± 5.31 | 64.47 ± 11.05 | 130.05 ± 5.02 |
| b6 | 4-CH3 | –H | 26.94 ± 4.79 | 77.22 ± 4.43 | 59.71 ± 2.67 | 99.19 ± 1.90 | 144.47 ± 8.05 |
| b7 | 3,5-dimethyl | –H | 32.32 ± 3.13 | 87.98 ± 9.39 | 96.77 ± 2.09 | 83.61 ± 23.16 | 183.61 ± 7.16 |
| b8 | 4-C6H5 | –H | 26.50 ± 0.26 | 28.43 ± 0.65 | 13.68 ± 1.31 | 40.07 ± 7.05 | 95.93 ± 4.28 |
| b9 | 4-CF3 | –H | 18.97 ± 1.49 | 22.08 ± 0.53 | 23.02 ± 1.24 | 91.69 ± 5.16 | 98.67 ± 7.67 |
| b10 | [d] [1,3] dioxole | –H | 28.23 ± 0.87 | 33.90 ± 2.71 | 38.09 ± 1.28 | 93.25 ± 3.53 | 193.25 ± 6.53 |
| b11 | 4-N(CH3)2 | –H | 32.85 ± 0.78 | 36.29 ± 1.21 | 46.78 ± 2.26 | 35.93 ± 4.28 | 99.19 ± 1.90 |
| b12 | naphthalene | –H | 33.42 ± 2.12 | 37.55 ± 6.14 | 76.38 ± 6.78 | 98.67 ± 7.67 | 161.47 ± 8.64 |
| SAHA | 4.85 ± 0.22 | 4.95 ± 0.13 | 4.75 ± 0.15 | 6.09 ± 1.32 | 9.09 ± 1.32 | ||
a
Data are shown as mean ± SD of three experiments. The compounds with promising inhibitory activities are highlighted in bold.