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. 2020 Apr 15;11:493. doi: 10.3389/fphar.2020.00493

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Copyright © 2020 Ma, Ma, Tu, Zheng, Chen and Lv

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isoproterenol (ISO) induces left atrial ischemia by increasing the heart rate and reducing blood pressure. An implantable telemetry transmitter was used for the continuous monitoring of temperature, ECG, and blood pressure. (A) Temperature analysis during the 48-h following ISO injection. (B) Heart rate during the 48-h following ISO injection. (C) Diastolic pressure during the 48-h following ISO injection. (D) Systolic pressure during the 48-h following ISO injection. (E) Representative ECG after injection of ISO. (F) Bar graph indicates creatinine kinase-MB (CK-MB) changes after ISO injection. **P < 0.01 versus CTL group.