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. 2020 Apr 15;11:270. doi: 10.3389/fneur.2020.00270

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Copyright © 2020 Tong, McCullagh and Iv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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67-years-old patient with a left medial frontal lobe brain metastasis from primary lung cancer treated with stereotactic radiosurgery. (A) Post-contrast T1-weighted image shows the treated enhancing lesion. (B) Multi-voxel 2D magnetic resonance spectroscopy acquired at 3T with grid placed on the lesion. (C) Spectra (from the voxel highlighted in yellow) shows findings of disease progression, with the presence of a lipid peak (indicative of necrosis), high Cho peak, and increased Cho/NAA and Cho/Cr ratios. Subsequent short-term follow-up MRI showed growth of the lesion (not shown), supporting the diagnosis of disease progression.