Table 3.
Characteristics of patients with normal cognition depending on disease group.
| LOEU-CN | CN | ||
|---|---|---|---|
| n | 19 | 11 | |
| Gender (female), n (%) | 7 (36.8%) | 4 (36.4%) | |
| Age at seizure onset, mean ± SD (years) | 65.1 ± 6.8 | 65.7 ± 7.7 | |
| Education, mean ± SD (years) | 11.1 ± 4 | 9.8 ± 4 | |
| EEG abnormalities, n (%) | 5 (26.3%) | 0 (0%)* | |
| CSF biomarkers, mean ± SD | |||
| Aβ42 (pg/mL) | 1387.8 ± 671.6 | 1022.4 ± 196.3 | |
| t-tau (pg/mL) | 247.4 ± 92.1 | 298.5 ± 135 | |
| p-tau (pg/mL) | 43.1 ± 11.3 | 49.7 ± 20.1 | |
| Aβ42/p-tau ratio | 31 ± 8.7 | 24.9 ± 13.1 | |
| Neuropsychological assessment scores, mean ±SD | |||
| MMSE | 28.3 ± 1.5 | 27.5 ± 1.6 | |
| CDT | 1.2 ± 1.6 | 1.1 ± 1.9 | |
| DIGIT F | 6.3 ± 1.3 | 6.1 ± 1.9 | |
| DIGIT B | 4.6 ± 0.9 | 4.7 ± 1.5 | |
| RAVLT imm | 39.7 ± 8 | 41.6 ± 8 | |
| RAVLT del | 7.9 ± 2.6 | 8.4 ± 2.3 | |
| RAVLT FP | 1.4 ± 2.1 | 1.1 ± 1.2 | |
| TMT A | 38.4 ± 11.5 | 42.8 ± 21 | |
| TMT B | 123 ± 46.4 | 131.3 ± 55.6 | |
| TMT B-A | 90.9 ± 32.4 | 90.8 ± 52.9 | |
| FAB | 16.6 ± 1.4 | 15.3 ± 3.6 | |
| FAS | 35.6 ± 9.4 | 41.4 ± 13.1 | |
| CF | 36.1 ± 7.6 | 41.3 ± 10.3 | |
| PM'47 | 29.8 ± 3.6 | 30.8 ± 3.4 | |
| CD | 9.8 ± 1.7 | 9.7 ± 1.1 | |
| CD L | 67.8 ± 3.8 | 67 ± 2.1 | |
LOEU, late onset epilepsy of unknown etiology; CN, cognitively normal; SD, standard deviation; EEG, electroencephalogram; CSF, cerebrospinal fluid; MMSE, Mini Mental State Examination; CDT, Clock Drawing Test; Digit F, Digit Span Forward; Digit B, Digit Span Backward; RAVLT, Rey Auditory Verbal Learning Test (Imm, Immediate Recall; Del, Delayed Recall; FP, False Positives). TMT, Trail Making Test; FAB, Frontal Assessment Battery; FAS, Phonemic/Letter Fluency (F,A,S); CF, Category Fluency; PM'47, Raven Colored Progressive Matrices'47; CD, Copying Drawings; CD L, Copying drawings with landmarks.
p < 0.05.
Categorical variables were compared with χ2 test.
Continuous variables were compared with t-test, with Bonferroni correction.