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Subcutaneous desensitization to adalimumab in patients with rheumatoid arthritis, ankylosing spondylitis and hypersensitivity reactions to adalimumab [24]
| Step | Time (min) | Dose (mg) | Concentration (mg/ml) | Volume injected (ml) |
|---|---|---|---|---|
| 1 | 0 | 0.5 | 0.5 | 1 |
| 2 | 30 | 0.75 | 5 | 0.15 |
| 3 | 60 | 1.25 | 5 | 0.25 |
| 4 | 90 | 2.5 | 5 | 0.5 |
| 5 | 120 | 5 | 50 | 0.1 |
| 6 | 150 | 10 | 50 | 0.2 |
| 7 | 180 | 20 | 50 | 0.4 |
Total time of desensitization 3 h. Cumulative dose 4 mg of adalimumab.
