Fig. 1.

The dot-stripe model of joint patterning. (A) Schematic of joint patterning. (B) Summary of gene expression patterns in the developing digit (see Table S1). (C) A Turing system that spontaneously breaks symmetry to form dots (Eqn 1). (D) A different Turing system that spontaneously breaks symmetry to form stripes (Eqn 2). (E) Schematic of the coupled dot-stripe mechanism (Eqn 4). (F) Simulation of the dot-stripe model results in evenly spaced dots (red) with interspersed stripes (blue). Arrows highlight expression patterns at the outer edges of the joint.