Figure 6.
Behavioural deficits of MPTP‐treated mice are ameliorated by treatment with roflupram or rolipram. (a) Schedule of behavioural experiments. (b) Roflupram (ROF) or rolipram (Roli) ameliorated locomotor behaviour in MPTP‐treated mice. (c) Roflupram or rolipram improved the performance of MPTP‐treated mice in the rotarod test. In (d, e, f, g), the mice walked for about 5 s on a running belt at a speed of 30 cm·s−1. The parameters of stride length (d), stride frequency (e), ataxia coefficient (f), and stride duration (g) of the mice were obtained for statistical analysis. Gait results indicated that roflupram or rolipram improved limb mobility in MPTP‐treated mice. Data are presented as individual values with means ± SD (n = 10 mice per group). # P < .05, significantly different from vehicle group. *P < .05, significantly different from MPTP‐treated group