Figure 10.

Roflupram (ROF) or rolipram (Roli) regulate the CREB/PGC‐1α pathway in the striatum of MPTP‐treated mice. (a) Tissue immunofluorescent staining of the striatum of mice was performed to detect the expression of PGC‐1α. Scale bar = 200 μm. (b) The striatum of each mouse was obtained, and the expression of PGC‐1α was measured by western blotting. (c) Tissue immunofluorescent staining of the striatum of mice was carried out to measure the expression of p‐CREB. Scale bar = 200 μm. (d) The striatum of each mouse was obtained, and the expression levels of p‐CREB and total CREB were measured by western blotting. Data are presented as mean ± SD (n = 5) and represent five independent experiments. ^# P < .05, significantly different from vehicle group. *P < .05, significantly different from MPTP‐treated group