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. 2020 Apr 15;10:370. doi: 10.3389/fonc.2020.00370

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Copyright © 2020 Wan, Hu, Wang, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of circRNA pathogenesis in osteosarcoma and their potential role in osteosarcoma therapy. (1) Tumor-suppressing and carcinogenic circRNAs are naturally present in normal cells and remain in relatively stable amounts. In osteosarcoma, tumor-suppressing circRNAs are downregulated while carcinogenic circRNAs are upregulated. The dysregulation of specific natural circRNAs contributes to osteosarcoma carcinogenesis. (2) miR-21 is a typical oncogenic miRNA in osteosarcoma. Artificial circular RNAs produced by chemical synthesis may block osteosarcoma progress by sponging miRNA-21 in the cytoplasm.