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. 2020 Apr 13;2020:3582648. doi: 10.1155/2020/3582648

Figure 2.

Figure 2

Immunologic function and Peli1 expression in autoimmune POI mouse models. (a) The levels of inflammatory factors were tested using the ovary homogenate by the ELISA assay. In the autoimmune POI group, the expression of IFN-γ increased while IL-10 decreased. (b) Flow cytometry analysis was performed for Treg cell sorting. The ratio of Treg cells in the autoimmune POI group was apparently lower. (c–e) qRT-PCR was performed to detect the relative expressions of Peli1 mRNA and miR-21. Peli1 mRNA quantitation in both PBMCs (c) and spleen Treg cells (d) and serum miR-21 (e) were significantly lower in the autoimmune POI group.