Table 3.
Correlation of TGF-β subtypes with OS and PFS in ovarian cancer patients with different TP53 mutation statuses.
| TGF-β subtypes | TP53 mutation | Cases | OS | P value | PFS | P value |
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||||
| TGF-β1 | Yes | 506 | 1.16 (0.93-1.46) | 0.19 | 0.79 (0.61-1.03) | 0.085∗ |
| No | 94 | 1.49 (0.86-2.58) | 0.15 | 0.57 (0.32-1.03) | 0.06 | |
|
| ||||||
| TGF-β2 | Yes | 506 | 0.86 (0.68-1.20) | 0.22 | 1.25 (1.00-1.56) | 0.049∗ |
| No | 94 | 1.84 (0.86-3.91) | 0.11 | 1.34 (0.76-2.37) | 0.3 | |
|
| ||||||
| TGF-β3 | Yes | 506 | 1.38 (1.10-1.73) | 0.0055∗ | 1.34 (1.07-1.67) | 0.0099∗ |
| No | 94 | 1.73 (0.99-3.02) | 0.05 | 1.68 (0.95-2.97) | 0.073 | |
|
| ||||||
| TGF-β4 | Yes | 506 | 1.28 (1.02-1.61) | 0.035∗ | 1.39 (1.10-1.76) | 0.0061∗ |
| No | 94 | 1.50 (0.87-2.58) | 0.14 | 1.31 (0.77-2.20) | 0.32 | |
∗ P < 0.05.