Figure 2.

In the Cell Reversion Theory a normal (differentiated) cell can complete a transition to an induced pluripotent stem cell (iPSC) state, of more stem cell like nature, in one or more steps [eventually passing through Multipotent Cell (MC) states], due to a perturbation (e.g., chemical or mechanical) to its conditions and/or its environment equilibrium. The iPSC can proliferate, and differentiate, in an unrestrained way generating a stressful cell environment, like hypoxia, a mutagenic condition. This cell, according to the presented hypothesis, can be at tumor origin. In the Somatic Mutation Theory successive mutations by carcinogenic events lead to the tumor phenotype.