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. 2019 Dec 6;30(4):2114–2127. doi: 10.1093/cercor/bhz226

Figure 4.

Figure 4

l-lactate does not rescue DAB-inhibited glycogen resynthesis. (A) TEM image of hippocampal excitatory synapses of mice treated with vehicle 24 hours after NOR training. In the astrocytic process contacting the presynaptic terminal, the glycogen granules are clearly visible, and the magnification shows the single granules inside the astrocyte. Scale bars: 100 nm and 50 nm. (B) Electron micrographs showing an increase of 221% in glycogen clusters’ size after learning in mice treated with vehicle versus control mice, and inhibitory effect of 1000 pmol DAB on glycogen granules’ resynthesis after learning that it is not rescued by l-lactate coadministration. Astrocytes processes are highlighted in blue and arrowheads indicated the glycogen granules’. Scale bar: 1 μm. (C) Corresponding violin plot of glycogen granules diameter. ****P < 0.0001; one-way analysis of variance, Tukey’s test (see Table S1).