Table 1.
Clinical characteristics by neoadjuvant treatment modality.
| Characteristic | Total n = 341 | ChemoXRT n = 107 | Chemotherapy alone n = 44 | Both n = 190 | p-value |
|---|---|---|---|---|---|
| Clinical stage, n (%) | |||||
| Resectable | 161 (47) | 103 (96) | 38 (86) | 20 (10) | <0.001 |
| BLR | 181 (53) | 4 (4) | 6 (14) | 170 (89) | |
| Age in years, median (IQR) | 65 (12) | 67 (14) | 64 (12) | 65 (13) | 0.07 |
| Gender (Female), n (%) | 169 (50) | 59 (55) | 24 (55) | 85 (45) | 0.19 |
| Charlson Comorbidity Index, median (IQR) | 3 (2) | 3 (2) | 2 (1) | 3 (2) | 0.05 |
| Body Mass Index, median (IQR) | 27 (7) | 27 (7) | 27 (6) | 27 (7) | 0.88 |
| Tumor size (cm), median (IQR) | 2.8 (2) | 2.3 (1.3) | 2.2 (1.1) | 3 (1.3) | <0.001 |
| CA19-9 at Diagnosis, U/mL, median (IQR)¥ | 188 (497) | 109 (293) | 216 (753) | 246 (616) | 0.13 |
| Preoperative CA19-9, U/mL, median (IQR)¥ | 33 (59) | 34 (61) | 49 (140) | 28 (50) | 0.32 |
| Postoperative CA19-9, U/mL, median (IQR)¥ | 17 (28) | 18 (22) | 15 (27) | 16 (30) | 0.97 |
| Elevated Preoperative CA19-9, n (%) | 138 (46) | 47 (48) | 23 (55) | 68 (42) | 0.31 |
| Elevated Postoperative CA19-9, n (%) | 20 (38) | 29 (55) | 19 (24) | 19 (40) | 0.18 |
| Histopathologic response, n (%) | |||||
| CR | 15 (4) | 4 (4) | 1 (2) | 10 (5) | 0.001 |
| nCR | 59 (17) | 13 (12) | 8 (18) | 38 (20) | |
| PR | 188 (55) | 65 (61) | 14 (32) | 109 (58) | |
| NR | 79 (23) | 25 (24) | 21 (48) | 33 (17) | |
| Pathological T stage, n (%) | |||||
| T0 | 15 (4) | 4 (4) | 1 (2) | 10 (5) | 0.91 |
| T1 | 107 (32) | 37 (35) | 15 (34) | 55 (29) | |
| T2 | 173 (51) | 52 (49) | 24 (55) | 97 (51) | |
| T3 | 46 (13) | 14 (13) | 4 (9) | 28 (15) | |
| Median Pathologic Tumor Size, (cm) | 2.5 (1.6) | 2.5 (1.7) | 2.5 (1.2) | 2.5 (1.5) | 0.86 |
| Node status, n (%) | |||||
| N0 | 208 (61) | 65 (61) | 19 (43) | 124 (65) | 0.06 |
| N1 | 97 (28) | 28 (26) | 18 (41) | 51 (27) | |
| N2 | 36 (11) | 14 (13) | 7 (16) | 15 (8) | |
| Margin status, n (%) | |||||
| Negative | 295 (87) | 93 (87) | 38 (86) | 164 (86) | 0.99 |
| Positive | 46 (13) | 14 (13) | 6 (14) | 26 (14) |