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. 2020 Apr 11;7:501–509. doi: 10.1016/j.toxrep.2020.04.001

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — The effects of benomyl on apoptosis/necrosis in SH-SY5Y cells evaluated by Annexin V with PI using flow cytometry. Apoptosis was induced in all tested concentrations, however, necrosis was induced only after incubation of the cells with 2 μM of benomyl (a). Interestingly, 1 and 4 μM of benomyl induced early apoptosis, whereas 2 and 6 μM of benomyl induced late apoptosis as shown in the representative quadrants (b). Apoptosis/necrosis results with Annexin V/PI were evaluated by utilizing fluorescent-labelled reagents and confocal microscopy (c). The results are presented as percentage of the total cell amount. The control cells were exposed to 1% DMSO. Error bars represent the standard deviation. *: p < 0.01 (b) compared to the control group.

Fig. 5 — The effects of benomyl on apoptosis/necrosis in SH-SY5Y cells evaluated by Annexin V with PI using flow cytometry. Apoptosis was induced in all tested concentrations, however, necrosis was induced only after incubation of the cells with 2 μM of benomyl (a). Interestingly, 1 and 4 μM of benomyl induced early apoptosis, whereas 2 and 6 μM of benomyl induced late apoptosis as shown in the representative quadrants (b). Apoptosis/necrosis results with Annexin V/PI were evaluated by utilizing fluorescent-labelled reagents and confocal microscopy (c). The results are presented as percentage of the total cell amount. The control cells were exposed to 1% DMSO. Error bars represent the standard deviation. *: p < 0.01 (b) compared to the control group.