TABLE 1.
Proteasome components in C. albicans
| Component and gene name in S. cerevisiaea |
C. albicans gene |
Essentiality in S. cerevisiae |
||
|---|---|---|---|---|
| orf19 name | Systematic name | Standard name | ||
| 20S core particle | ||||
| PRE1 | orf19.4025 | C5_05310W_A | PRE1 | Essential |
| PRE2 | orf19.2233 | C2_06820C_A | PRE2 | Essential |
| PRE3 | orf19.6991 | C3_05560W_A | PRE3 | Essential |
| PRE4 | orf19.4230 | C5_02230W_A | PRE4 | Essential |
| PRE5 | orf19.7178 | C7_04020C_A | PRE5 | Essential |
| PRE6 | orf19.544.1 | CR_04550W_A | PRE6 | Essential |
| PRE7 | orf19.2755 | C4_02470C_A | PRE7 | Essential |
| PRE8 | orf19.7335 | CR_09380W_A | PRE8 | Essential |
| PRE10 | orf19.6582 | C7_01470C_A | PRE10 | Essential |
| PUP1 | orf19.7605 | CR_10300W_A | PUP1 | Essential |
| PUP2 | orf19.709 | CR_06750C_A | PUP2 | Essential |
| PUP3 | orf19.1336 | C7_03390C_A | PUP3 | Essential |
| SCL1 | orf19.5378 | C3_00770C_A | SCL1 | Essential |
| PRE9 | orf19.350 | C3_03520C_A | PRE9 | Nonessential |
| 19S regulatory particle lid | ||||
| RPN3 | orf19.3054 | C1_03520W_A | RPN3 | Essential |
| RPN5 | orf19.4032 | C5_05380W_A | RPN5 | Essential |
| RPN6 | orf19.1299 | C4_03790W_A | RPN6 | Essential |
| RPN7 | orf19.7286 | CR_08910C_A | RPN7 | Essential |
| RPN8 | orf19.3168 | C5_02030W_A | RPN8 | Essential |
| RPN11 | orf19.7264 | C1_14460W_A | RPN11 | Essential |
| RPN12 | orf19.213 | C2_08930W_A | RPN12 | Essential |
| RPN9 | orf19.1993 | C2_01320W_A | RPN9 | Nonessential |
| SEM1 | orf19.3122.2 | C4_06880C_A | SEM1 | Nonessential |
| 19S regulatory particle base | ||||
| RPT1 | orf19.441 | C1_05240C_A | RPT1 | Essential |
| RPT2 | orf19.5440 | C3_00290W_A | RPT2 | Essential |
| RPT3 | orf19.5793 | C2_03060W_A | PR26/RPT3 | Essential |
| RPT4 | orf19.482 | CR_04000W_A | RPT4 | Essential |
| RPT5 | orf19.3123 | C4_06870W_A | RPT5 | Essential |
| RPT6 | orf19.3593 | C2_08780W_A | RPT6 | Essential |
| RPN1 | orf19.4956 | C1_13300C_A | RPN1 | Essential |
| RPN2 | orf19.5260 | C1_12050W_A | RPN2 | Essential |
| RPN10 | orf19.4102 | C2_06150C_A | RPN10 | Nonessential |
| RPN13 | orf19.1058 | C1_04230W_A | RPN13 | Nonessential |
a
S. cerevisiae annotations were obtained from Finley et al. (20). PRE2, PRE3, and PUP1 are proteolytically active in S. cerevisiae.