FIG 4.

Infiltration of lymphocytes into the neuroparenchyma of SIVE conventional progressor macaques. Shown are immunohistochemistry images representing confirmed SIVE RMs, one with rapid progressor (RP) to SIVE (H538) and one with conventional progressor (CP) to SIVE (H886). (A to E) Slides were stained with CD68/CD163 to identify myeloid/macrophages (A), CD3 to identify lymphocytes (B), CD4 to identify CD4⁺ T cells (C), CD8 to identify CD8⁺ T cells (D), and CD20 to identify B cells (E). All sections were then stained with DAB substrate (brown) and counterstained with hematoxylin (blue). Black arrows point to multinucleated giant cells.