Figure 7.

Schematic representation of the interplay between ER stress/unfolded protein response (UPR) activation and autophagy in response to Zn (II)-curc in mutp53H273-carrying cancer cells. Diagram illustration describes the pathways contributing to mutp53H273 degradation by autophagy and the role of ER stress/UPR activation. The arrows indicate activation, and the red lines indicate blocking. The possible starting even could be the Zn-induced mutp53 folding/unfolding balance, as previously reported [8,11,36,37].