Table 3.
Association between single nucleotide polymorphism genotypes of the lymphocytes activation gene 3 and the clinical characteristics of multiple sclerosis.
| Clinical Characteristics | LAG3 Gene | |||||
|---|---|---|---|---|---|---|
| rs2365095 CC/CT/TT |
rs1922452 AA/GA/GG |
rs951818 AA/AC/CC |
rs870849 CC/TC/TT |
rs188255 CC/GC/GG |
rs11227 GG/TG/TT |
|
| Body Mass Index ** | 0.281 a 2.554 b |
0.358 a 2.068 b |
0.320 a 2.290 b |
0.397 a 1.856 b |
0.340 a 2.168 b |
0.699 a 0.718 b |
| MS Duration ** | 0.811 a 0.420 b |
0.942 a 0.118 b |
0.798 a 0.452 b |
0.716 a 0.668 b |
0.880 a 0.256 b |
0.647 a 0.872 b |
| Age at MS Onset ** | 0.842 a 0.346 b |
0.861 a 0.300 b |
0.598 a 1.030 b |
0.555 a 1.180 b |
0.973 a 0.054 b |
0.834 a 0.364 b |
| EDSS Score at Presentation ** | 0.367 a 2.012 b |
0.795 a 0.460 b |
0.791 a 0.470 b |
0.954 a 0.094 b |
0.509 a 1.354 b |
0.280 a 2.564 b |
| No. of Relapses before Drug Treatment * | 0.725 a 0.812 b |
0.112 a 4.433 b |
0.294 a 2.485 b |
0.980 a 0.078 b |
0.483 a 1.810 b |
0.313 a 2.262 b |
| Vit. D Deficiency * | 0.253 a 2.658 b |
0.664 a 0.888 b |
0.789 a 0.629 b |
0.444 a 1.926 b |
0.332 a 2.292 b |
0.953 a 0.096 b |
| Patient Age ** | 0.973 a 0.056 b |
0.582 a 1.084 b |
0.248 a 2.812 b |
0.359 a 2.060 b |
0.669 a 0.806 b |
0.803 a 0.438 b |
| Family History * | 0.833 a 0.471 b |
0.291 a 2.555 b |
0.485 a 1.460 b |
0.353 a 2.120 b |
0.438 a 1.817 b |
0.285 a 2.613 b |
| Comorbidity * | 0.799 a 0.436 b |
0.028 a 6.923 b |
0.089 a 4.869 b |
0.130 a 4.071 b |
0.481 a 1.801 b |
0.994 a 0.012 b |
| Smoking * | 0.656 a 1.057 b |
0.476 a 1.548 b |
0.727 a 0.666 b |
0.561 a 1.138 b |
0.925 a 0.283 b |
0.945 a 0.140 b |
| Form of MS * | 0.620 a 2.342 b |
0.467 a 3.724 b |
0.503 a 3.567 b |
0.305 a 6.873 b |
0.070 a 6.924 b |
0.577 a 4.104 b |
| Sex * | 0.539 a 1.316 b |
0.879 a 0.275 b |
0.939 a 0.139 b |
0.727 a 0.711 b |
0.548 a 1.218 b |
0.551 a 1.188 b |
a: P-Value < 0.05 is considered significant, b: Chi-squared value. * Pearson’s Chi-squared test was used to determine genotype-phenotype association. ** Analysis of variance (ANOVA) test was used to determine genotype-phenotype association.