Figure 4.

Influence of lipid mediators on ER stress-dependent pathway.Disorders in synthesis or action of exogenous factors, like lipid mediators (black) may lead to the generation and accumulation of abnormal proteins (AP). In consequence these proteins induce endoplasmic reticulum stress and activation of pro-apoptotic factors (red font). Moreover, ER stress leads to activation of mitochondrial pathway (yellow). On the other hand, during endoplasmic reticulum stress also some cytoprotective mechanisms are activated (green font).