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Left: Inhibitory effects of colonic flavonoid metabolites and sulfaphenazole (SULF, positive control; 20 μM each) on the CYP2C9-catalyzed diclofenac (5 μM) hydroxylation. O-desmethylangolensin (DESMA) was the sole compound which considerably inhibited the enzyme. Right: Concentration-dependent inhibition of CYP2C9 by DESMA and SULF (* p < 0.05; ** p < 0.01). Means and SEM values demonstrated are derived from three independent experiments.
