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Inhibitory effects of DESMA, RES, PHLO, and the positive controls (sulfaphenazole and ketoconazole) on CYP2C9 or CYP3A4 enzymes. Data are derived from three independent experiments.
| CYP2C9 assay | Substrate concentration (μM) | IC50 (μM) | α 1 |
| Sulfaphenazole | 5.0 | 1.32 | 1.00 |
| DESMA | 5.0 | 6.60 | 5.00 |
| CYP3A4 assay | Substrate concentration (μM) | IC50 (μM) | α 1 |
| Ketoconazole | 5.0 | 0.24 | 1.00 |
| RES | 5.0 | 4.86 | 20.3 |
| PHLO | 5.0 | 7.92 | 33.0 |
1α: IC50 of the inhibitor divided by the IC50 value of the positive control.
