Table 2.
Effect of succinamide derivatives on antioxidant enzymes and lipid peroxidation.
| Groups | GST (µmol/mg of Protein) |
GSH (µmol CDNB Conjugate/min/mg of Protein) |
Catalase (µmol H2O2/min/mg of Protein) |
LPO (nmol/TBARS/mg of Protein) |
|---|---|---|---|---|
| Saline | 88.25 ± 0.15 | 67.90 ± 0.56 | 165.6 ± 1.650 | 85.15 ± 0.91 |
| Scopolamine | 27.8 ± 2.89 ### | 26.78 ± 2.78 ### | 88.80 ± 3.890 ### | 123.70 ± 3.71### |
| 2g | 45.1 ± 3.8 * | 33.90 ± 1.23 * | 125.1±3.230 ** | 87.45±8.90 ** |
| 2i | 43.78 ± 3.7 * | 32.78 ± 0.90 * | 120.5 ± 8.890 * | 96.89 ± 4.56 * |
| 2d | 44.10 ± 3.78 * | 33.33 ± 0.67 * | 127.4 ± 4.900 ** | 92.78 ± 2.78 * |
| 2b | 50.13 ± 3.89 ** | 35.33 ± 0.67 ** | 130.9 ± 6.890 ** | 85.12 ± 4.89 ** |
| 2e | 55.23 ± 2.89 *** | 37.23 ± 0.78 *** | 135.9 ± 8.890 *** | 78.89 ± 6.89 *** |
Symbols *** or ### show significant difference at p < 0.001, while * and ** show significant difference at p < 0.05 and p < 0.01, respectively. The symbol * shows a significant difference relative to scopolamine and # shows significant difference relative to saline. Data are shown as mean± SEM (n=5). Abbreviations: GST, glutathione S-transferase; GSH, glutathione; TBARS, thiobarbituric acid reactive substances; LPO, lipid peroxidation; CAT, catalase.