Table 3.
Association between HDL parameters and risk of PTDM in 351 RTRs.
| Tertiles | 1 | 2 | 3 | ||
|---|---|---|---|---|---|
| HDL cholesterol, mg/dL | >59 | 47–58 | <47 | Per 1SD | p value |
| Cases | 7 | 14 | 18 | 39 | |
| Crude analysis | 1.00 (ref) | 2.07 (0.84–5.14) | 3.29 (1.37–7.88) | 0.53 (0.36–0.80) | 0.002 |
| Model 1 | 1.00 (ref) | 1.99 (0.79–5.05) | 3.01 (1.22–7.43) | 0.55 (0.36–0.83) | 0.005 |
| Model 2 | 1.00 (ref) | 1.78 (0.69–4.63) | 2.89 (1.16–7.23) | 0.53 (0.34–0.83) | 0.006 |
| Model 3 | 1.00 (ref) | 2.21 (0.85–5.74) | 3.15 (1.26–7.92) | 0.55 (0.36–0.83) | 0.004 |
| Model 4 | 1.00 (ref) | 1.90 (0.74–4.90) | 2.60 (1.02–6.61) | 0.59 (0.39–0.91) | 0.018 |
| Model 5 | 1.00 (ref) | 2.62 (1.01–6.80) | 2.71 (1.05–6.99) | 0.59 (0.38–0.92) | 0.021 |
| Model 6 | 1.00 (ref) | 1.92 (0.76–4.90) | 2.53 (1.00–6.48) | 0.61 (0.40–0.94) | 0.024 |
| Large HDL particles µmol/L | >2.9 | 1.6–2.9 | <1.6 | Per 1SD Log | p value |
| Cases | 7 | 11 | 21 | 39 | |
| Crude analysis | 1.00 (ref) | 1.70 (0.66–4.39) | 3.59 (1.53–8.46) | 0.66 (0.51–0.84) | 0.001 |
| Model 1 | 1.00 (ref) | 1.46 (0.55–3.85) | 3.18 (1.29–7.87) | 0.63 (0.47–0.84) | 0.002 |
| Model 2 | 1.00 (ref) | 1.28 (0.47–3.47) | 3.06 (1.22–7.66) | 0.61 (0.44–0.84) | 0.002 |
| Model 3 | 1.00 (ref) | 1.78 (0.66–4.80) | 3.43 (1.38–8.52) | 0.60 (0.45–0.81) | 0.001 |
| Model 4 | 1.00 (ref) | 1.51 (0.55–4.10) | 3.06 (1.18–7.88) | 0.64 (0.47–0.86) | 0.004 |
| Model 5 | 1.00 (ref) | 1.37 (0.51–3.73) | 2.70 (1.05–6.91) | 0.67 (0.48–0.93) | 0.017 |
| Model 6 | 1.00 (ref) | 1.49 (0.53–3.94) | 2.83 (1.10–7.29) | 0.68 (0.50–0.93) | 0.017 |
| HDL size, nm | >9.2 | 8.9–9.2 | <8.9 | Per 1SD | p value |
| Cases | 5 | 13 | 21 | 39 | |
| Crude analysis | 1.00 (ref) | 3.05 (1.09–8.56) | 4.57 (1.72–12.12) | 0.47 (0.31–0.72) | 0.001 |
| Model 1 | 1.00 (ref) | 2.78 (0.98–7.89) | 4.09 (1.47–11.35) | 0.48 (0.31–0.76) | 0.002 |
| Model 2 | 1.00 (ref) | 2.60 (0.91–7.47) | 3.68 (1.30–10.42) | 0.50 (0.31–0.80) | 0.004 |
| Model 3 | 1.00 (ref) | 3.56 (1.24–10.21) | 4.63 (1.65–13.02) | 0.48 (0.32–0.75) | 0.001 |
| Model 4 | 1.00 (ref) | 2.90 (1.01–8.33) | 3.80 (1.34–10.80) | 0.51 (0.33–0.81) | 0.004 |
| Model 5 | 1.00 (ref) | 2.10 (0.73–6.07) | 3.01 (1.06–8.56) | 0.62 (0.40–0.98) | 0.040 |
| Model 6 | 1.00 (ref) | 2.85 (1.00–8.15) | 3.46 (1.18–10.21) | 0.58 (0.36–0.93) | 0.025 |
HRs (95% CIs) were derived from Cox proportional hazard models. Multivariable model 1 was adjusted for age, sex, and BMI. Model 2 was adjusted for model 1 variables, alcohol consumption, smoking, and physical activity; Model 3 was adjusted for model 1 variables and treatment (lipid-lowering medication, anti-hypertensive medication, prednisolone dose, calcineurin inhibitors, and proliferation inhibitors); Model 4 was adjusted for model 1 variables and eGFR, urinary albumin excretion, CMV infection, time after transplantation; Model 5 was wadjusted for model 1 variables and HbA1c; Model 6 was adjusted for model 1 variables and systolic blood pressure, fasting plasma glucose, and triglycerides.