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. 2020 Mar 2;10(3):383. doi: 10.3390/biom10030383

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Representative microcomputed tomography (µCT) image of the proximal third of the tibia for each rat group: 1 (BM + PBMT) (lyophilized bovine bone matrix with photobiomodulation therapy), 2 (BM + HFB) (lyophilized bovine bone matrix plus heterologous fibrin biopolymer) and 3 (BM + HFB + PBMT) (lyophilized bovine bone matrix plus heterologous fibrin biopolymer with photobiomodulation therapy) in the periods of (A) 14 and (B) 42 days. (A1,B1) Three-dimensional coronal section shows the cortical region of the defect, biomaterial particles (yellow arrow). (A2,B2) Two-dimensional sagittal section shows the cortical and medullary region of the defect filled by BM, defect in the cortical bone (red arrows).