Figure 5.
In mdx mice ADAMTS-5 blockade improved the contractile function of fast EDL muscles. (A) Treatment with the ADAMTS-5 mAb increased the specific isometric force (sPo) output of EDL muscles. (B) During 4 min of intermittent 60 Hz stimulation, the relative fatigability of EDL muscles from mdx mice treated with the ADAMTS-5 mAb was reduced and the relative force recovery was also improved. In soleus muscles, ADAMTS-5 blockade had no significant effect on (C) isometric strength or (D) fatigability and force recovery. *P < 0.05 and **P < 0.001, main effect treatment, 2-way GLM-ANOVA. N = 17-19 mice.