Figure 6.

Fast twitch EDL muscle morphology is unaffected by ADAMTS-5 blockade in mdx mice. EDL fiber size as assessed by minimal Feret’s diameter (A), the proportion of centrally nucleated fibers (B) and percent area of degeneration and mononuclear infiltrate (C) did not significantly between EDL muscle cross sections from IgG and ADAMTS-5 mAb treated mdx mice (A–C; n = 7). The mRNA transcript abundance of Tgfβ1 (D) and Mcp-1 (E) did not significantly differ between EDL muscles from IgG or ADAMTS-5 mAb treated mdx mice. N = 7 mice for morphometric analyses and n = 13 mice for gene expression analysis. Scale bar = 100 µm.