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. 2020 Mar 24;10(3):491. doi: 10.3390/biom10030491

Table 1.

In vitro Potency and Selectivity of Methyl Substituted 2-Oxoesters.

Compound Structure GIVA cPLA2 GIVA iPLA2 GIVA sPLA2
% Inhibitiona XI(50) %
Inhibitiona 		%
Inhibitiona
GK452 graphic file with name biomolecules-10-00491-i001.jpg >95% 0.000078 ± 0.00001b N.D.b,c N.D.b,c
GK587 graphic file with name biomolecules-10-00491-i002.jpg >95% 0.00036 ± 0.00007 N.D.c N.D.c
GK639 graphic file with name biomolecules-10-00491-i003.jpg >95% 0.0012 ± 0.00008 N.D.c N.D.c

a % Inhibition at 0.091 mole fraction of each inhibitor; b data taken from ref. [23]. c N.D. signifies compounds with less than 25% inhibition (or no detectable inhibition).