Table 4.
Inhibition concentrations 50% (IC50s) of the investigated compounds in different cell lines. The cells were treated for 48 h. Cisplatin was used as a positive control. Selectivity index (SI) was calculated as [IC50 in MRC-9 cells] / [IC50 in PC-3 cells].
| IC50, µM | ||||||||||
| Compound | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Cisplatin | |
| Cell line | PC-3 | 6.73 | 5.24 | 2.1 | 16.37 | 15.23 | 19.26 | 14.86 | 9.24 | 21.0 |
| 22Rv1 | 20.14 | 13.85 | 6.38 | 29.53 | 35.81 | 46.9 | 30.51 | 17.51 | 4.53 | |
| MRC-9 | 48.51 | 37.57 | 16.82 | 27.18 | 24.61 | >50 | 24.4 | 23.95 | 15.12 | |
| Selectivity index (MRC-9 vs. PC-3) |
7.21 | 7.17 | 7.99 | 1.66 | 1.62 | >2.6 | 1.64 | 2.59 | 0.72 | |