Figure 1.

The collagen fiber arrangement of the canine cornea (A) is consistent with other mammals, with an intertwining pattern similar to that of the rabbit cornea (B) but with markedly less intertwining when compared with the human cornea (C) [8]. The anterior-most aspect (30%) of the canine cornea (A) exhibits a thin superficial region of intertwining collagen fibers whereas the posterior aspect (70%) exhibits a parallel collagen fiber arrangement, nearly identical to the rabbit (B). By contrast, the human cornea (C) exhibits extensive collagen fiber intertwining throughout the majority of the cornea and smaller area of parallel fiber arrangement in the posterior aspect. Scale bar equivalent to 1 mm (A), 200 μm (A inset, B and C). The faint vertical lines seen in the (A inset), B,C represent artifact from the image stitching process. Figures B and C are reprinted from Acta Biomater., Vol. 10, Iss. 2, Thomasy SM et al., “Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium”, pp. 785–791, Copyright (2014), with permission from Elsevier.