Table 1.
Correlation between tetraspanins and clinical prognosis in human cancers.
| Tetraspanins | Cancer Types Correlated with Poor Prognosis | Cancer Types Correlated with Good Prognosis | References |
|---|---|---|---|
| TSPAN1 (NET-1) | GC, CRC, PCC | [20,21,22] | |
| TSPAN2 | Lung ADC | [23] | |
| TSPAN5 (NET-4) | GC | [12] | |
| TSPAN7 (Talla1, TM4SF2, CD231) | NSCLC | [24] | |
| TSPAN8 (Co-029) | GC, HCC, BC, EOC, NPC | [25,26,27,28,29] | |
| TSPAN9 (NET-5, PP1057) | GC | [30] | |
| TSPAN13 (NET-6) | BC | [31] | |
| TSPAN15 (NET-7) | ESCC | [32] | |
| TSPAN17 | GBM | [33] | |
| TSPAN24 (CD151, Peta3) | HCC, GBC, BC, HGSC, NSCLC, PC, GC, CRC | [34,35,36,37,38,39,40] | |
| TSPAN27 (CD82, KAI1) | CCRCC | ESCC, NSCLC, PCC, BC, GBC, CRC | [17,41,42,43,44,45,46] |
| TSPAN28 (CD81, Tapa1) | BC, MM, AML | GBC | [47,48,49,50] |
| TSPAN29 (CD9, p24) | GC | NSCLC, BC, CRC, PCC, NHL, ESCC, OSCC, EM, HNSCC, UBC, MM, GBC, NB, AML | [14,15,16,17,18,42,51,52,53,54,55,56,57,58,59] |
| TSPAN30 (CD63) | Lung ADC | [13] |
Abbreviations: GC (gastric carcinoma), CRC (colorectal carcinoma), PCC (pancreatic carcinoma), Lung ADC (Lung adenocarcinoma), NSCLC (non-small-cell lung cancer), BC (breast cancer), EOC (epithelial ovarian cancer), NPC (nasopharyngeal carcinoma), ESCC (esophageal squamous cell carcinoma), GBM (glioblastoma), HCC (hepatocellular carcinoma), GBC (gallbladder carcinoma), HGSC (high-grade serous ovarian cancer), PC (prostate cancer), CCRCC (clear cell renal cell carcinoma), MM (multiple myeloma), AML (acute myeloid leukemia), NHL (non-Hodgkin lymphoma), OSCC (oral squamous cell carcinoma), EM (endometrial cancer), HNSCC (head and neck squamous cell carcinoma), UBC (urothelial bladder carcinoma) and NB (neuroblastoma).