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. 2020 Feb 27;8(3):45. doi: 10.3390/biomedicines8030045

Figure 3.

Figure 3

Effect of CuONPs on amyloid precursor protein (APP) expression. (A) Time course of APP expression in response to CuONPs (10 µM); (B) dose 0–100 µM, response of CuONPs on APP expression in SH-SY5Y cells (left) and PC12 cells (right). In (A), cells were harvested at the indicated time points and blotted for APP and β-actin. In (B), doses of CuONPs in the range (0–100 µM) and TNFα (50 ng /mL) were used and cells harvested at 6 h and lysates blotted for APP and β-actin. Densitometric analysis from 3 independent experiments were plotted and Student’s t-test were performed to determine levels of significance, * p < 0.05, ** p < 0.01 CuONPs or TNFα treated compared to control.