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Protein–protein interaction (PPI) in murine NAGLU−/− brain tissue proteome. The PPI network was explored by STRING (Search Tool for the Retrieval of Interacting Genes) software. The cluster analysis shows “Metabolic Pathways” (p 1.44 × 10−6), “Cytoskeletal Regulation” (p 2.16 × 10−5) and “Synaptic vesicle trafficking” (p 8.40 × 10−3) as significant pathways according to KEGG (Kyoto Encyclopedia of Genes and Genomes) database.
