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. 2020 Feb 26;10(3):355. doi: 10.3390/biom10030355

Table 1.

Dysregulated proteins in NAGLU−/− mouse brains compared to WT.

Swiss-Prot Code Gene Name Protein Description Fold NSAF p Value Subcellular Localization
Q545B6 Stmn1 Stathmin −12.6 0.00002 CK
Q9QYX7 Pclo Protein piccolo −8.4 0.00101 CK, GA
Q6P9K8 Caskin1 Caskin-1 −3.8 0.00262 CK
A8DUK2 Hbbt1 Beta-globin −3.4 0.00008 C
Q4VAE3 Tmem65 Transmembrane protein 65 −3.3 0.00374 M, PM
Q8CHF1 mKIAA0531 Kinesin-like protein (Fragment) −3.2 0.00232 CK
P17563 Selenbp1 Selenium-binding protein 1 −3.2 0.00046 CK, N
Q4KMM3 Oxr1 Oxidation resistance protein 1 −3 0.00036 M, N
A2AS98 Nckap1 Nck-associated protein 1 −2.9 0.00209 CK, PM
C7G3P1 Ppfia3 MKIAA0654 protein (Fragment) −2.6 0.00328 CK
Q8BVQ5 Ppme1 Protein phosphatase methylesterase 1 −2.5 0.00345 N
Q3UVN5 Nsfl1c Putative uncharacterized protein −2.5 0.00002 CK, GA, N
Q9R0Q6 Arpc1a Actin-related protein 2/3 complex subunit 1A −2.4 0.00036 CK, N, PM
Q3TF14 Ahcy Adenosylhomocysteinase −2.4 0.00329 CK, N
Q9CX86 Hnrnpa0 Heterogeneous nuclear ribonucleoprotein A0 −2.4 0.00165 N
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 −2.4 0.00671 CK, N, PM
O54991 Cntnap1 Contactin-associated protein 1 −2.3 0.00626 PM
B0V2P5 Dmxl2 DmX-like protein 2 −2.3 0.01109 PM
E9Q8N8 Slc4a4 Anion exchange protein −2.3 0.0011 PM
B1AQX9 Srcin1 SRC kinase-signaling inhibitor 1 −2.3 0.0004 CK
P24472 Gsta4 Glutathione S-transferase A4 −2.3 0.00125 M
Q3UK83 Hnrnpa1 Putative uncharacterized protein −2.2 0.00047 ERS, N
D3Z4J3 Myo5a Unconventional myosin-Va −2.2 0.00636 CK, C, ER, En, GA, Ly, Pe
Q61411 Hras GTPase HRas −2.2 0.00583 C, GA, N, PM
Q9Z0X1 Aifm1 Apoptosis-inducing factor 1, mitochondrial −2.1 0.00398 CK, M, N
B2L107 Vsnl1 Visinin-like protein 1 −2.1 0.00018 C
Q9DBF1 Aldh7a Alpha-aminoadipic semialdehyde dehydrogenase −2.1 0.02264 C, M, N
Q3TJF2 Ola1 Obg-like ATPase 1 −2.1 0.00001 CK, C, N
Q8VDD5 Myh9 Myosin-9 −2 0.01358 C, CK, N, PM
Q9JJK2 Lancl2 LanC-like protein 2 −2 0.00232 C, CK, N, PM
E9Q2L2 Dlg2 Disks large homolog 2 −2 0.00218 PM
Q91VR5 Ddx1 ATP-dependent RNA helicase DDX1 −2 0.00216 C, M, N
Q9JHU4 Dync1h1 Cytoplasmic dynein 1 heavy chain 1 −2 0.00407 CK, N
Q99PU5 Acsbg1 Long-chain-fatty-acid--CoA ligase ACSBG1 −1.9 0.01942 ER, PM
Q64010 Crk Adapter molecule crk −1.9 0.0031 CK, PM
P14733 Lmnb1 Lamin-B1 −1.9 0.02293 CK, N
P54775 Psmc4 26S protease regulatory subunit 6B −1.9 0.03099 CK, N
A0A1S6GWI0 Ndufa8 NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 8 −1.8 0.00156 M
Q3U741 Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a −1.8 0.00085 C, N
Q3TIQ2 Rpl12 Putative uncharacterized protein −1.8 0.01139 C, N
P70168 Kpnb1 Importin subunit beta-1 −1.7 0.00011 C, M, N
Q80TZ3 Dnajc6 Putative tyrosine-protein phosphatase auxilin −1.7 0.00164 C
Q5DTG0 Atp8a1 Phospholipid-transporting ATPase (Fragment) −1.7 0.00428 ER, GA, PM
Q9QXS1 Plec Plectin −1.7 0.00377 C, CK, PM
Q921F2 Tardbp TAR DNA-binding protein 43 −1.7 0.00786 N
B2RX08 Sptb Spectrin beta chain −1.7 0.00319 C, CK, PM
Q3TKG4 Psmc3 Putative uncharacterized protein (Fragment) −1.6 0.00396 N
Q3UH59 Myh10 Myosin-10 −1.6 0.02527 C, CK, PM
Q9JM76 Arpc3 Actin-related protein 2/3 complex subunit 3 −1.6 0.01437 C, N
A0A1S6GWJ8 Uncharacterized protein –1,5 0.02713
Q3UN60 Mpp6 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_b −1.5 0.00085 PM
Q91XV3 Basp1 Brain acid soluble protein 1 −1.5 0.00001 N, PM
Q07076 Anxa7 Annexin A7 −1.5 0.01183 C, ER, ERS, N, PM
Q3UY05 Ndufs8 Putative uncharacterized protein −1.4 0.00008 M
A0A0R4J0Q5 Lmnb2 Lamin-B2 −1.4 0.03275 CK, N
Q4FJX9 Sod2 Superoxide dismutase −1.4 0.01379 M
Q91VN4 Chchd6 MICOS complex subunit Mic25 −1.4 0.01573 C, M
O88737 Bsn Protein bassoon −1.3 0.00915 C, GA
Q3UWW9 Psmd11 Putative uncharacterized protein −1.3 0.01386 C, N
O08788 Dctn1 Dynactin subunit 1 −1.3 0.01243 CK, C, ERS, N
A0A0R4J275 Ndufa12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 −1.3 0.0197 C, M
Q63932 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 −1.3 0.01951 CK, C, ER, En, GA, M, N, PM
Q61361 Bcan Brevican core protein −1.3 0.01264 ERS
Q3V117 Acly ATP-citrate synthase −1.3 0.0078 C, M, N, PM
Q8R570 Snap47 Synaptosomal-associated protein 47 −1.3 0.00248 C, PM
Q9DCS9 Ndufb10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 −1.2 0.01688 M
P14824 Anxa6 Annexin A6 −1.2 0.01378 C, En, ERS, Ly, M, N, PM
P54071 Idh2 Isocitrate dehydrogenase [NADP], mitochondrial −1.2 0.00039 C, M, Pe
Q7TSJ2 Map6 Microtubule-associated protein 6 −1.2 0.00159 CK, GA
Q8BGN3 Enpp6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 −1.2 0.03099 ERS, PM
Q9CZD3 Gars Glycine--tRNA ligase −1.2 0.01474 C, ERS, M
A0A0R4J083 Acadl Long-chain-specific acyl-CoA dehydrogenase, mitochondrial −1.2 0.03611 M
Q8CGK3 Lonp1 Lon protease homolog, mitochondrial −1.1 0.01936 C, M, N
E9Q7Q3 Tpm3 Tropomyosin alpha-3 chain −1.1 0.00355 CK, C
Q8BWT1 Acaa2 3-ketoacyl-CoA thiolase, mitochondrial −1.1 0.04478 M
P61226 Rap2b Ras-related protein Rap-2b −1.1 0.03025 C, En, ERS, PM
Q8R5C5 Actr1b Beta-centractin −1.1 0.00172 CK
E9Q0J5 Kif21a Kinesin-like protein KIF21A −1.1 0.04345 CK, C, PM
B9EKR1 Ptprz1 Receptor-type tyrosine-protein phosphatase zeta −1.1 0.01214 ERS, PM
Q6ZQ38 Cand1 Cullin-associated NEDD8-dissociated protein 1 −1 0.00177 C, GA, N
Q9JI91 Actn2 Alpha-actinin-2 −1 0.00286 CK, PM
P68040 Rack1 Receptor of activated protein C kinase 1 −1 0.03823 CK, M, N, PM
E9PUL5 Prrt2 Proline-rich transmembrane protein 2 −1 0.0411 PM
F6SEU4 Syngap1 Ras/Rap GTPase-activating protein SynGAP −1 0.03268 PM
Q8CHG1 Dclk1 MKIAA0369 protein (Fragment) −1 0.02306 PM
Q61490 Alcam CD166 antigen −1 0.03414 PM
D3Z656 Synj1 Synaptojanin-1 −1 0.02126 PM
H3BIV5 Akap5 A-kinase anchor protein 5 −1 0.01709 CK, PM
Q8VD37 Sgip1 SH3-containing GRB2-like protein 3-interacting protein 1 −1 0.04017 CK, PM
W6PPR4 Ank3 480-kDa ankyrinG −1 0.00579 CK, C, PM
Q9CWS0 Ddah1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 −0.9 0.04649 M
Q11011 Npepps Puromycin-sensitive aminopeptidase −0.9 0.00505 C, N
Q3TXE5 Canx Putative uncharacterized protein −0.9 0.00488 ER, PM
Q3UAG2 Pgd 6-phosphogluconate dehydrogenase, decarboxylating −0.9 0.02403 C
Q99JX6 Anxa6 Annexin −0.9 0.04313 C, En, ERS, Ly, M, N, PM
A0A0G2JEG8 Amph Amphiphysin −0.9 0.00912 CK, PM
Q99P72 Rtn4 Reticulon-4 −0.9 0.01061 ER, N, PM
Q49S98 Slc32a1 Putative uncharacterized protein −0.9 0.04098 PM
B2RQQ5 Map1b Microtubule-associated protein 1B −0.9 0.03443 CK, C, PM
D3Z2H9 Tpm3 Uncharacterized protein −0.9 0.02982 CK, C
Q6ZQ61 Matr3 MCG121979, isoform CRA_c (Fragment) −0.8 0.01811 N
Q3TE45 Sdhb Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial −0.8 0.01667 M, N, PM
Q0VF55 Atp2b3 Calcium-transporting ATPase −0.8 0.03416 PM
Q3UEG9 Flot2 Putative uncharacterized protein −0.8 0.02632 CK, En, PM
Q91V61 Sfxn3 Sideroflexin-3 −0.8 0.00937 M
P61164 Actr1a Alpha-centractin −0.8 0.03531 CK
Q571M2 Hspa4 MKIAA4025 protein (Fragment) −0.7 0.00487 C, ERS, N
Q9Z2Y3 Homer1 Homer protein homolog 1 −0.7 0.01584 C, PM
E9Q455 Tpm1 Tropomyosin alpha-1 chain −0.7 0.04225 C
A2A5Y6 Mapt Microtubule-associated protein −0.7 0.04838 CK, C, N, PM
A0A1S6GWH1 Uncharacterized protein –0,7 0.02404
P35486 Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial −0.6 0.00552 M, N
Q8CC13 Ap1b1 AP complex subunit beta −0.6 0.03216 C, GA
E9Q2W9 Actn4 Alpha-actinin-4 (Fragment) −0.6 0.00847 CK, C, N
Q8BVE3 Atp6v1h V-type proton ATPase subunit H −0.6 0.02175 C, Ly
A0A0A6YY91 Ncam1 Neural cell adhesion molecule 1 (Fragment) −0.6 0.0182 CK, PM
Q3TYK4 Prkar1a Putative uncharacterized protein −0.6 0.01177 CK, C, PM
P12960 Cntn1 Contactin-1 −0.6 0.02931 PM
Q3TPZ5 Dctn2 Dynactin 2 −0.6 0.00054 CK, C
A0A1L1SV25 Actn4 Alpha-actinin-4 −0.6 0.0286 CK, C, N
P19246 Nefh Neurofilament heavy polypeptide −0.5 0.04106 CK, M, N, PM
A0A0R4J117 Igsf8 Immunoglobulin superfamily member 8 −0.5 0.04908 PM
Q68FG2 Sptbn2 Spectrin beta chain −0.5 0.04372 CK, C, ER, En, GA
Q80YU5 Mog Myelin oligodendrocyte glycoprotein (Fragment) −0.5 0.02477 C, ER, M, PM
E9QB01 Ncam1 Neural cell adhesion molecule 1 −0.5 0.03648 C, PM
Q01853 Vcp Transitional endoplasmic reticulum ATPase −0.5 0.03249 C, ER, N
P09041 Pgk2 Phosphoglycerate kinase 2 −0.4 0.03696 C
Q7TPR4 Actn1 Alpha-actinin-1 −0.4 0.01557 CK, N, PM
P63011 Rab3a Ras-related protein Rab-3A −0.4 0.0162 C, En, Ly, PM
P09411 Pgk1 Phosphoglycerate kinase 1 −0.3 0.01617 C, ERS, PM
O08599 Stxbp1 Syntaxin-binding protein 1 0.1 0.03134 CK, C, M, PM
A0A0A0MQA5 Tuba4a Tubulin alpha chain (Fragment) 0.2 0.01472 CK
P68369 Tuba1a Tubulin alpha-1A chain 0.2 0.02299 CK, En
Q52L87 Tuba1c Tubulin alpha chain 0.3 0.0146 CK, N
P50396 Gdi1 Rab GDP dissociation inhibitor alpha 0.3 0.03464 GA
P60710 Actb Actin, cytoplasmic 1 0.3 0.02793 CK, C, N, PM
Q9CZU6 Cs Citrate synthase, mitochondrial 0.3 0.00075 M
P05202 Got2 Aspartate aminotransferase, mitochondrial 0.3 0.03387 M, PM
P63038 Hspd1 60 kDa heat shock protein, mitochondrial 0.3 0.02215 CK, ER, En, ERS, GA, M, PM
E9Q912 Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 0.3 0.00467 CK, ER, M
B2CSK2 Heat shock protein 1-like protein 0.3 0.00172
O88935 Syn1 Synapsin-1 0.3 0.03624 CK, C, GA, N
P68033 Actc1 Actin, alpha cardiac muscle 1 0.3 0.00986 CK
P08249 Mdh2 Malate dehydrogenase, mitochondrial 0.3 0.00731 M
Q03265 Atp5a1 ATP synthase subunit alpha, mitochondrial 0.3 0.00169 M, N, PM
Q99KI0 Aco2 Aconitate hydratase, mitochondrial 0.3 0.00087 C, M
P17879 Hspa1b Heat shock 70 kDa protein 1B 0.4 0.00362 CK, C, M, N, PM
O08553 Dpysl2 Dihydropyrimidinase-related protein 2 0.4 0.00004 CK, C, M, PM
Q5FW97 EG433182 Enolase 1, alpha non-neuron 0.4 0.00346 C
Q64332 Syn2 Synapsin-2 0.4 0.01708 PM
Q3TQ70 Gnb1 Beta1 subnuit of GTP-binding protein 0.4 0.01897 PM
P62631 Eef1a2 Elongation factor 1-alpha 2 0.4 0.00011 N
P80316 Cct5 T-complex protein 1 subunit epsilon 0.4 0.04942 CK, C
Q8CE19 Syn2 Putative uncharacterized protein 0.4 0.02198 PM
Q3UA81 Eef1a1 Elongation factor 1-alpha 0.4 0.00003 CK, C, M, PM
Q8C2Q7 Hnrnph1 Heterogeneous nuclear ribonucleoprotein H 0.4 0.01261 C, N
Q9D6F9 Tubb4a Tubulin beta-4A chain 0.4 0.00031 CK
P17751 Tpi1 Triosephosphate isomerase 0.4 0.00008 C
P48774 Gstm5 Glutathione S-transferase Mu 5 0.4 0.01045 C, ERS
P18872 Gnao1 Guanine nucleotide-binding protein G(o) subunit alpha 0.4 0.00334 PM
Q3UYK6 Slc1a2 Amino acid transporter 0.4 0.03711 PM
Q8BVI4 Qdpr Dihydropteridine reductase 0.4 0.02048 C, M
Q9D2G2 Dlst Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0.4 0.00639 M, N, PM
Q3UD06 Atp5c1 ATP synthase subunit gamma 0.4 0.00728 M
P68372 Tubb4b Tubulin beta-4B chain 0.4 0.00008 CK
P99024 Tubb5 Tubulin beta-5 chain 0.4 0.00005 CK, C, M
P56480 Atp5b ATP synthase subunit beta, mitochondrial 0.4 0.00166 M, PM
E9QKR0 Gnb2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.4 0.0162 PM
B2RSN3 Tubb2b Tubulin beta chain 0.4 0.00013 CK
Q7TMM9 Tubb2a Tubulin beta-2A chain 0.4 0.0001 CK
P63017 Hspa8 Heat shock cognate 71 kDa protein 0.4 0.0001 CK, C, En, ERS, Ly, N, PM
Q3TIC8 Uqcrc1 Putative uncharacterized protein 0.4 0.00014 C, M
P26443 Glud1 Glutamate dehydrogenase 1, mitochondrial 0.4 0.00008 M
Q3TYV5 Cnp 2′,3′-cyclic-nucleotide 3′-phosphodiesterase 0.5 0.00001 ERS
B7U582 Heat shock protein 70-2 0.5 0.00001
Q8BH95 Echs1 Enoyl-CoA hydratase, mitochondrial 0.5 0.03689 M
Q6P1J1 Crmp1 Crmp1 protein 0.5 0.00045 CK, C, N
B2CY77 Rpsa Laminin receptor (Fragment) 0.5 0.01872 C, ERS, N, PM
Q922F4 Tubb6 Tubulin beta-6 chain 0.5 0.00002 CK
Q9ERD7 Tubb3 Tubulin beta-3 chain 0.5 0.00003 CK
Q60930 Vdac2 Voltage-dependent anion-selective channel protein 2 0.5 0.00247 M
P14152 Mdh1 Malate dehydrogenase, cytoplasmic 0.5 0.00092 C, M
A6ZI44 Aldoa Fructose-bisphosphate aldolase 0.5 0.00156 CK, C, ERS, M, N, PM
Q80X68 Csl Citrate synthase 0.5 0.00001 N
A2AQ07 Tubb1 Tubulin beta-1 chain 0.5 0.00009 CK
P01831 Thy1 Thy-1 membrane glycoprotein 0.6 0.00272 C, ER, PM
A0A1S6GWG6 Uncharacterized protein 0,6 0.00144
Q3UBZ3 Capza2 Putative uncharacterized protein 0.6 0.03767 CK
Q9D6M3 Slc25a22 Mitochondrial glutamate carrier 1 0.6 0.02851 M
O08749 Dld Dihydrolipoyl dehydrogenase, mitochondrial 0.6 0.00293 M, N
Q91VA7 Idh3b Isocitrate dehydrogenase [NAD] subunit, mitochondrial 0.6 0.0105 M
O88712 Ctbp1 C-terminal-binding protein 1 0.6 0.00177 N
Q8C3L6 Atp6v1b1 Putative uncharacterized protein 0.6 0.04137 PM
P70333 Hnrnph2 Heterogeneous nuclear ribonucleoprotein H2 0.6 0.00158 N
P14094 Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 0.7 0.00001 PM
O55100 Syngr1 Synaptogyrin-1 0.7 0.03643 PM
Q9R0P9 Uchl1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 0.7 0.00142 C, ER, PM
P05063 Aldoc Fructose-bisphosphate aldolase C 0.7 0.00002 C, M
Q61990 Pcbp2 Poly(rC)-binding protein 2 0.8 0.03331 C, N
Q8R464 Cadm4 Cell adhesion molecule 4 0.8 0.01837 PM
P21279 Gnaq Guanine nucleotide-binding protein G(q) subunit alpha 0.9 0.04159 C, N, PM
Q00898 Serpina1 Alpha-1-antitrypsin 1-5 1.2 0.04259 ER, ERS, GA
P63330 Ppp2ca Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.4 0.00163 CK, C, N, PM
P03995 Gfap Glial fibrillary acidic protein 1.4 0.00001 CK, Ly

CK, Cytoskeleton; C, Cytosol; ER, Endoplasmic reticulum; En, Endosome; ERS, Extracellular region or secreted; GA, Golgi apparatus; Ly, Lysosome; M, Mitochondrion; N, Nucleus; Pe, Peroxisome PM, Plasma Membrane.