Table 5c.
Cut off values, area under curve of ROC, and Youden index of CTX, OC, and ON in discriminating healthy from smoker periodontitis based on BL (33%) and PPD (6 mm).
| Cut-off (ng/mL) | Se (%) | Sp (%) | AUC | 95% CI | P | YI | ||
|---|---|---|---|---|---|---|---|---|
| BL (33.33%) | CTX | 15.88 | 80.0 | 36.78 | 0.534 | 0.399–0.665 | 0.729 | 0.167 |
| 17.37 | 70.0 | 40.82 | ||||||
| 20.19 | 50.0 | 53.06 | ||||||
| OC | 11.41 | 100 | 46.94 | 0.809 | 0.686–0.900 | <0.001 | 0.534 | |
| 19.24 | 80.0 | 73.47 | ||||||
| 25.99 | 60.0 | 87.76 | ||||||
| ON | 55.6 | 80.0 | 40.82 | 0.611 | 0.475–0.735 | 0.298 | 0.238 | |
| 58.11 | 70.0 | 53.06 | ||||||
| 108.36 | 30.0 | 93.88 | ||||||
| Cut-off (ng/mL) | Se (%) | Sp (%) | AUC | 95% CI | P | YI | ||
| PPD (6 mm) | CTX | 17.37 | 92.31 | 47.31 | 0.632 | 0.497–0.754 | 0.0732 | 0.401 |
| 20.19 | 76.92 | 60.87 | ||||||
| 71.56 | 100 | 0 | ||||||
| OC | 16.45 | 92.31 | 65.22 | 0.811 | 0.688–0.901 | <0.001 | 0.575 | |
| 18.23 | 84.62 | 67.39 | ||||||
| 29.21 | 38.46 | 95.65 | ||||||
| ON | 57.65 | 84.62 | 54.35 | 0.701 | 0.567–0.813 | 0.009 | 0.433 | |
| 58.11 | 84.62 | 58.70 | ||||||
| 92.14 | 53.85 | 80.43 | ||||||
Se: sensitivity; Sp: specificity; ROC: receiver operator characteristic; AUC: area under curve; 95% CI: 95% confidence interval (CI); YI: Youden Index = Se + Sp − 1; PPD: probing pocket depth; BOP: bleeding on probing; BL: bone loss; CTX: deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen; OC: osteocalcin; ON: osteonectin.