Figure 6.

Topological Invariance of Amyloid Addiction

(A and B) Comparison of APRs that can be fully suppressed by a single codon-compatible mutation (rescuable) with those that cannot, in terms of SCOP class (A) and secondary structure element (B) in which they occur, following the FoldX code for secondary structure annotation (^∗, unclassified; 3, 3-10 helix; a, α helix; b, parallel beta conformation; B, antiparallel beta conformation; E, β strand; c, random coil; m, helix C-cap; n, helix N-cap; T, turn).

(C) Example of a conserved APR in an all-α fold (SCOP class a): the VPS9 domain of Rab5 (Homo sapiens; PDB: 1TXU).

(D) Example of a conserved APR in the α/β fold (SCOP class c): glutaminyl-peptide cyclotransferase (Homo sapiens; PDB: 2AFW).

(E) Example of a conserved APR in an α+β fold (SCOP class d): E3 ubiquitin-protein ligase NRDP1 (Homo sapiens; PDB: 2FZP).

(F) Schematic representation illustrating the APR addiction principle.

The source files (Data S1) and R-scripts (Data S2) used to generate this figure are available.