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. Author manuscript; available in PMC: 2020 Apr 22.
Published in final edited form as: Anal Chem. 2019 Sep 26;91(20):12917–12927. doi: 10.1021/acs.analchem.9b02904

Figure 5.

Figure 5.

PEDOT/CNT-functionalized MEAs are sensitive for resting DA. (a) Average (n = 5, SEM omitted for clarity) in vitro SWV DA calibrations conducted at PEDOT/CNT-functionalized MEAs in aCSF reveal a concentration-dependent DA peak at 0.18 V. aCSF subtraction reveals the average (±SEM) peaks to be Gaussian in shape (inset). (b) PEDOT/CNT-functionalized MEAs exhibit linear sensitivity for DA (±SEM). Uncoated gold MEA sites (±SEM, n = 5, isolated view shown in inset) are completely insensitive for DA detection, exhibiting both a nonlinear and negative sensitivity trend. PEDOT/CNT nanocomposite coatings significantly increase MEA sensitivity for DA (* one-way ANOVA, p < 0.05). (c) Schematic drawing of in vivo MEA positioning. Two PEDOT/CNT-functionalized MEA electrode sites were located within the dorsal striatum (DS) (green and black), and one PEDOT/CNT-functionalized MEA electrode site was located within the non-DA rich S1FL (red). (d) Electrodes located within the DS (green and black) showed clear, nomifensine-dependent DA detection (20 mg/kg ip injection at t = 30 min, dashed blue vertical line), whereas the electrode located within the S1FL (red) shows no nomifensine-dependent DA detection.