NCT00578669.

Study characteristics
Methods	Study design: RCT Country: USA Setting and recuirment method not specified
Participants	Participants had elevated depression symptoms. 206 participants randomized; 48% female; average age 44; average cigarettes per day 21; mean FTND 5.7
Interventions	Fluoxetine. 20 mg once daily, 8 weeks prior to target quit date and weeks thereafter Placebo. Given according to schedule detailed above Common components: nicotine patch as well as "standard smoking cessation treatment"
Outcomes	Smoking cessation: 7‐day ppa at 12 months. Validated by CO and saliva cotinine Adverse events: measured for a period of one year
Funding Source	None specified
Author conflicts of interest	None specified
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No relevant information given
Allocation concealment (selection bias)	Unclear risk	No relevant information given
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Placebo controlled, but no further information on blinding provided
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Clinical trial registry implies 100%, but not explicitly, so we concluded there was not sufficient information given