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. 2020 Apr 7;33(4):860–879. doi: 10.1021/acs.chemrestox.9b00476

Table 2. Examples of Some Coactivators That Have Been Shown to Associate with AHR or Its Complexa.

coactivator reference notes
BRCA-1 [284, 285] interaction with both AHR and ARNT
BRG-1 [286, 287] interaction with AHR, enhances complex activity
CARM-1 [288] interaction with AHR
CoCoA [289] interaction with both AHR and ARNT
COUP-TF1 [290] interaction with AHR and not ARNT
ERα [290] interaction with AHR and not ARNT
ERRα [290] interaction with AHR and not ARNT
ERAP140 [291] interaction with AHR–ARNT complex
GAC63 (GRIP1) [292] interaction with AHR
Mediator [97] interaction with AHR–ARNT complex
P160 (NcoA-1-3) [117] interaction with both AHR and ARNT
NcoA-4 [93] interaction with both AHR and ARNT
P300 [117, 293, 294] interaction with both AHR and ARNT
PGC-1 [288] interaction with AHR
RB [295] interaction with AHR
RIP140 [296, 297] interaction with AHR, cross talk with ERα
SHP [298] interaction with ARNT and not AHR
SMRT [291, 299] interaction with AHR–ARNT complex and AHR
SRC1 (NcoA-1) [283, 288] interaction with AHR Q-rich region
SRC2 (NcoA-2) [288] interaction with AHR
SRC3 (NcoA-3) [288] interaction with AHR
TAF4 [283] interaction with AHR Q-rich region
TAF6 [283] interaction with AHR Q-rich region
TBP [283] interaction with AHR Q-rich region
TIF2 [283] interaction with AHR Q-rich region
TRAP220 [288] interaction with AHR
TRIP230 [300] interaction with ARNT
SIN3A [301] enhances complex activity
a

This table of examples was generated by a cross reference of the topics, “Ah receptor” and “Coactivator” in the “Web of Science” search engine of scientific publications, apps.webofknowledge.com (8/1/2019). It was then supplemented with information found in two reports on the topic.79,117 Clear, alternative names of coactivators are given in parentheses. The table is meant to represent the diversity of known AHR–coactivator interactions and is not intended to be an exhaustive list.