Fig. 5.

Comparison of different replication sequencing methods. a Replication timing ratios where higher ratios correspond to earlier replicating regions (i), replication timing profile (ii), active/repressed chromatin regions (iii), strong OK-seq strand switch coordinates (iv), OK-seq replication-fork directionality ratios (v) and NS-seq (replication origin) tracks (vi) for K562 cell line. b OK-seq strand switches in the four segments of replication. c NS-seq peak abundances in the four replication timing phases. d Comparison of analysis time between deeptools bamCompare and BAMscale for replication timing data