Table 2.

Uni- and multivariable analyses of (a) cancer-specific and (b) overall survival in non-irradiated CRCs

Variable	Univariable		Multivariable
	HR (95%CI)	p	HR (95%CI)	p
(a) Cancer survivala
Female gender	1.17 (0.74–1.83)	0.503
Right colon	1.00 (Reference)		1.00 (Reference)
Left colon	1.45 (0.77–2.71)	0.251	1.14 (0.60–2.17)	0.682
Rectum	1.54 (0.88–2.70)	0.128	1.04 (0.58–1.89)	0.888
Stage I	0.09 (0.02–0.37)	0.001	0.08 (0.02–0.33)	< 0.001
Stage II	0.34 (0.17–0.68)	0.002	0.25 (0.12–0.51)	< 0.001
Stage III	1.00 (Reference)		1.00 (Reference)
Stage IV	3.08 (1.91–4.97)	<0.001	3.43 (2.02–5.84)	< 0.001
CRP (per 10mg/l)	1.09 (1.01–1.17)	0.022	1.08 (1.00–1.15)	0.042
Age (per 10 years)	1.24 (1.02–1.51)	0.032	1.59 (1.30–1.95)	< 0.001
(b) Overall survivalb
Female gender	1.10 (0.78–1.54)	0.60
Right colon	1.00 (Reference)		1.00 (Reference)
Left colon	0.79 (0.49–1.28)	0.49	0.87 (0.52–1.44)	0.58
Rectum	1.18 (0.80–1.73)	0.79	1.10 (0.73–1.64)	0.66
Stage I	0.48 (0.28–0.81)	0.006	0.40 (0.23–0.70)	0.001
Stage II	0.71 (0.46–1.10)	0.12	0.50 (0.32–0.80)	0.003
Stage III	1.00 (Reference)		1.00 (Reference)	Reference
Stage IV	2.40 (1.53–3.76)	< 0.001	3.13 (1.93–5.06)	< 0.001
CRP (per 10mg/l)	1.05 (0.99–1.12)	0.096	1.08 (1.01–1.15)	0.037
Age (per 10 years)	2.00 (1.68–2.38)	< 0.001	1.66 (1.25–2.20)	< 0.001

^aCRP and age were included as continuous variables in steps of 10 units. The multivariable analysis was stratified for gender. Other deaths used as competing events

^bCRP and age were included as continuous variables in steps of 10 units divided by 10. The multivariable analysis was stratified for gender and a time-dependent correction term for age (1.10/year, 95% CI 1.03–1.17, p=0.004) was added to account for deviation from the Cox model assumption of constant hazard ratio over time