Table 3.

Multivariable adjusted risk ratios (RR_a) for analgesic consumption according to clinical factors

	Preoperative (0–3 months)	Postoperative (9–12 months)
	Any analgesic**	Any analgesic**	Acetaminophen	NSAID	Opioid
Hip replacement
Laterality:bilateral	1.1 (0.999–1.2)	0.82 (0.64–1.04)	0.34 (0.17–0.68)	1.02 (0.77–1.3)	0.67 (0.38–1.2)
Harris Hip Score***
Poor (< 70)	1	1	1	1	1
Fair (70–80)	0.77 (0.63–0.94)	0.78 (0.54–1.1)	0.65 (0.29–1.4)	0.91 (0.61–1.3)	0.58 (0.22–1.6)
Good or excellent (> 80)	0.49 (0.30–0.82)	0.60 (0.28–1.3)	1.36 (0.05–2.5)	0.72 (0.31–1.7)	–
Knee replacement
Laterality:bilateral	1.1 (1.02–1.2)	0.86 (0.77–0.96)	0.77 (0.62–0.96)	0.91 (0.78–1.1)	0.56 (0.42–0.76)
UKA (vs TKA)	0.72 (0.61–0.84)	0.83 (0.69–1.002)	0.45 (0.28–0.72)	0.99 (0.79–1.2)	0.52 (0.32–0.85)
KSS Knee Score***
Poor (< 60)	1	1	1	1	1
Fair (60–70)	0.81 (0.71–0.92)	0.94 (0.82–1.1)	0.83 (0.62–1.1)	1.03 (0.86–1.2)	0.73 (0.50–1.05)
Good or excellent (> 70)	0.78 (0.64–0.95)	0.88 (0.70–1.1)	0.81 (0.52–1.3)	0.94 (0.70–1.3)	0.82 (0.49–1.4)
KSS Function Score***
Poor (< 60)	1	1	1	1	1
Fair (60–70)	0.94 (0.84–1.1)	1.03 (0.90–1.2)	1.3 (1.02–1.7)	0.90 (0.73–1.1)	0.91 (0.65–1.3)
Good or excellent (> 70)	0.90 (0.82–0.99)	0.89 (0.80–1.00)	0.95 (0.75–1.2)	0.97 (0.83–1.1)	0.73 (0.55–0.97)

RR (95% CI) adjusted with age (continuous), gender, Charlson Comorbidity Index, BMI (continuous), laterality (unilateral vs bilateral), and use of antidepressant 1 year before surgery

**Acetaminophen, NSAID, opioid

***Preoperative HHS missing on 2138 (34.3%) patients and KSS Knee Score on 2617 (34.9%) patients and KSS Function Score on 2645 (35.3%) patients