Fig. 2.

Copy number abnormality and concordance analyses across histological subtypes. a Dots represent the copy number profile abnormality (CPA) score for liquid biopsies (LBs). Boxplots indicate distributions. The gray box (bottom) shows the 1% false discovery rate (FDR) cutoff. Dot colors (positive/negative) clarify their position with respect to this box. The fractions on top summarize the latter. b Identical to a, yet dots represent solid biopsies (SBs). c Scatter plot evaluating the SB/LB Pearson correlation (r; defined as in Fig. 1) in relation to the CPA score of LBs. Dot size indicates days between biopsies and is quadratically scaled. The dense gray box (left) represents the 1% FDR cutoff. The horizontal solid lines are means, embedded within non-dense boxes, showing their uncertainty (95% CI). Boxplots (right) indicate the underlying distributions per histological subtype. Means, standard errors, and boxplots are weighted by dot size