Figure 3.

BD simulations of receptor binding as a function of time t_m. Model parameters were κ_rec = 20 pN/μm for single receptor binding strength and initial concentration c₀ = 4/μm², D_rec = 0.03, …, 0.07 μm²/s. (A) The mean number of bound receptors during subsequent stages of bead indentation and receptor diffusion is shown. See Videos S1 and S2. (B) Stepwise binding of single receptors on bead and analyzed from BD simulations (black tracks) and averaged trace in color are shown. To see this figure in color, go online.