FIG. 4.
Topical CFTRact-K267 reverses corneal epithelial injury in mice following LDC. (A) Experimental protocol. (B) Representative photos of LG staining of cornea at days 2, 4, and 6 after LDC in vehicle and CFTRact-K267-treated eyes. (C) Photos scored using a 12-point standard scale (see the Methods section). (Top) Absolute LG scores on day 2 (2 days after LDC, before treatment) days 4 and 6 in vehicle and CFTRact-K267-treated eyes (mean ± SEM, 12 eyes, *P < 0.01, by t-test). (Bottom) Data shown for each individual eye (black lines) as the change in LG scores from those on day 2. Averaged data are shown as red lines (mean ± SEM, 12 eyes, *P < 0.05 compared with day 2, by t-test). (D) Photos scored using a comparative grading method (see the Methods section). Data shown for individual mice as Comparative LG grade for CFTRact-K267- versus vehicle-treated eyes (mean ± SEM, 12 eyes, *P < 0.01 compared with day 2, by t-test). Color images are available online.