Table 2.
APACHE II, SOFA, LAC, and PCT in survivors and nonsurvivors and their predictive for hospital mortality
| Biomarkers | All (n = 626) | Survivors (n = 378) | Nonsurvivors (n = 248) | P value | AUROC (95%CI) | Cut-off |
|---|---|---|---|---|---|---|
| APACHE II | 18 (14, 25) | 16 (11, 20) | 25 (19, 30) | 0.000 | 0.823 (0.789–0.856) | 21.5 |
| PCT | 1.5 (0.2, 9.9) | 1.3 (0.2, 10.0) | 2.1 (0.2, 10.9) | 0.290 | 0.525 (0.479–0.572) | 0.8 |
| ALB | 26 (22.7, 30.0) | 27.0 (23.0, 31.2) | 25.5 (22.0, 8.5) | 0.001 | 0.419 (0.373–0.464) | 27.7 |
| Temperature | 37.6 (36.7, 38.7) | 37.5 (36.6, 38.5) | 37.6 (36.8, 38.9) | 0.022 | 0.554 (0.508–0.600) | 38.9 |
| SOFA initial | 7.0 (4.0, 10.0) | 6.0 (4.0, 8.0) | 9.0 (6.0, 13.0) | 0.000 | 0.715 (0.674–0.756) | 6.7 |
| SOFA mean | 6.3 (3.9, 9.7) | 5.0 (3.1, 7.3) | 9.3 (6.3, 12.7) | 0.000 | 0.774 (0.737–0.811) | 5.8 |
| SOFA max | 8.0 (5.0, 12.0) | 6.7 (4.0, 10.0) | 12.0 (8.0, 15.0) | 0.000 | 0.767 (0.730–0.804) | 7.3 |
| △SOFA1 | 3.0 (2.0, 5.0) | 3.0 (1.0, 5.0) | 3.0 (2.0, 5.0) | 0.004 | 0.567 (0.521–0.613) | 2.5 |
| △SOFA2 | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 1.0 (0.0, 3.8) | 0.000 | 0.634 (0.589–0.680) | 0.5 |
| LAC initial | 1.7 (1.1, 2.7) | 1.6 (1.1, 2.4) | 2.0 (1.2, 3.3) | 0.000 | 0.609 (0.564–0.655) | 1.9 |
| LAC mean | 1.6 (1.1, 2.4) | 1.4 (1.0, 2.0) | 2.0 (1.4, 3.4) | 0.000 | 0.697 (0.656–0.739) | 2.2 |
| LAC max | 2.3 (1.6, 3.5) | 2.0 (1.3, 2.8) | 2.8 (2.0, 6.4) | 0.000 | 0.699 (0.657–0.740) | 3.3 |
| △LAC1 | 1.1 (0.6, 2.1) | 0.9 (0.5, 1.6) | 1.5 (0.8, 3.4) | 0.000 | 0.650 (0.606–0.695) | 2.3 |
| △LAC2 | 0.2 (0.0, 0.9) | 0.0 (0.0, 0.6) | 0.5 (0.0, 2.2) | 0.000 | 0.630 (0.584–0.676) | 1.5 |
AUROC area under the receiver operating characteristic curve, APACHE II Acute Physiology and Chronic Health Evaluation II, ALB albumin, CI confidence interval, PCT procalcitonin, SOFA Sequential Organ Failure Assessment, LAC lactate, LAC initial lactate on the first day after admission, LAC mean average lactate for 7 consecutive days, LAC max maximum lactate for 7 consecutive days, LAC min minimum lactate for 7 consecutive days, △LAC1 LAC max – LAC min, △LAC2 LAC max – LAC initial, SOFA initial SOFA score on the first day after admission, SOFA mean average SOFA score for 7 consecutive days, SOFA max maximum SOFA score for 7 consecutive days, SOFA min minimum SOFA score for 7 consecutive days, △SOFA1 SOFA max – SOFA min, △SOFA2 SOFA max – SOFA initial. Data are expressed as medians (interquartile range). Comparison of the two groups was conducted using the Mann–Whitney test