Table 3.
Univariate and multivariate analysis of the risk factors for hospital mortality
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | |
| APACHE II | 1.216 (1.177–1.257) | 0.000 | 1.188 (1.144–1.235) | 0.000* |
| ALB | 0.962 (0.938–0.986) | 0.002 | NI | |
| Temperature | 1.139 (1.010–1.285) | 0.034 | 0.847 (0.724–0.991) | 0.038* |
| SOFA initial | 1.220 (1.167–1.276) | 0.000 | NI | |
| SOFA mean | 1.312 (1.247–1.381) | 0.000 | 1.089 (1.021–1.162) | 0.010* |
| SOFA max | 1.271 (1.215–1.329) | 0.000 | NI | |
| △SOFA1 | 1.097 (1.030–1.168) | 0.004 | NI | |
| △SOFA2 | 1.271 (1.173–1.377) | 0.000 | 1.193 (1.081–1.316) | 0.000* |
| LAC initial | 1.236 (1.135–1.345) | 0.000 | NI | |
| LAC mean | 1.743 (1.492–2.035) | 0.000 | NI | |
| LAC max | 1.285 (1.200–1.375) | 0.000 | NI | |
| △LAC1 | 1.267 (1.176–1.364) | 0.000 | NI | |
| △LAC2 | 1.423 (1.263–1.604) | 0.000 | 1.156 (1.027–1.301) | 0.017* |
NI not included in multivariate survival analysis. Risk is presented as hazard ratio and 95% confidence interval (CI) with an increment of 1 unit of the biomarker concentration. The following covariates, deemed important clinical variables, were considered in the multivariable models: APACHE II, temperature, SOFA mean, △SOFA2, △LAC2. *P < 0.05. APACHE II Acute Physiology and Chronic Health Evaluation II, ALB albumin, SOFA Sequential Organ Failure Assessment, LAC lactate, OR odds ratio